SMART: find protein domains
You have a new protein you want to find out about, but no one has worked on it before. Do you use the Entrez conserved domains thing, or do a Blink or BLAST? Naah, you know that SMART (Simple Modular Architecture Research Tool) is way cooler and will give you the results in an easy to examine format. Just plug in your sequence, hit "Sequence SMART" and go. It will tell you that you have a DEAD box helicase or a SH3 domain and then you're on the road to success. Or something like that.