What is the world's hottest hot sauce? Blair's 16 Million Reserve ought to be hot enough to send you hot heads to the hospital or an early grave, that is if you even dare to try it. You see, Blair's 16 Million Reserve isn't actually a sauce, it's a 1ml pharmaceutical grade vial filled with pure Capsaicin crystals. Pure Capsaicin is rated at around 16 million Scoville Units, the highest heat level possible. (via The Green Head)